The Threshold of Toxicological Concern Concept in Risk Assessment
نویسندگان
چکیده
منابع مشابه
The Threshold of Toxicological Concern (TTC) in risk assessment.
The Threshold of Toxicological Concern (TTC) is a level of human intake or exposure that is considered to be of negligible risk, despite the absence of chemical-specific toxicity data. The TTC approach is a form of risk characterisation in which uncertainties arising from the use of data on other compounds are balanced against the low level of exposure. The approach was initially developed by t...
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A scientific rationale is provided for estimating acceptable daily intake values (ADIs) for compounds with limited or no toxicity information to support pharmaceutical manufacturing operations. These ADIs are based on application of the "thresholds of toxicological concern" (TTC) principle, in which levels of human exposure are estimated that pose no appreciable risk to human health. The same c...
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Low dose, low risk; very low dose, no real risk. Setting a pragmatic threshold below which concerns become negligible is the purpose of thresholds of toxicological concern (TTC). The idea is that such threshold values do not need to be established for each and every chemical based on experimental data, but that by analyzing the distribution of lowest or no-effect doses of many chemicals, a TTC ...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2005
ISSN: 1096-0929,1096-6080
DOI: 10.1093/toxsci/kfi169